Studies on the protein synthesis in poisoning. I. The inhibitory action of CC1-4 on the incorporation of C-14-2-glycine into the protein of mouse liver.

The incorporation of C14-2-glycine into the subcellular fractions of liver, kidney and serum proteins was observed in mice receiving CCl4 injections. The results showed a marked inhibitory effect of CCl4 on incorporation of C14-glycine into each subcellular fraction of the liver, but not of the kidney. The inhibition of the C14-glycine incorporation was most marked in mitochondria, moderate in soluble protein and minimal in microsomes, in the groups of mice given two injections of CCl4. In the animals given CCl. injection, serum albumin is decreased with the decreased incorporation of C14-glycine into the albumin but β-globulin fraction is increased. The former will be the result of the decreased albumin synthesis in the poisoned liver and the latter will be correlated with the fatty degeneration of liver. ∗PMID: 14481229 [PubMed indexed for MEDLINE] Copyright c ©OKAYAMA UNIVERSITY MEDICAL SCHOOL Acta Mcu. Okayama 15, (1961) . STUDIES ON THE PROTEIN SYNTHESIS IN POISONING I. THE INHIBITORY ACTION OF CCI4 ON THE INCORPORATION OF C14-2-GLYCINE INTO THE PROTEIN OF MOUSE LIVER*